Drug Delivery Enhancement
The Supercritical Fluids team has developed different patented green processes for the preformulation of APIs
is a patented and innovative coating process using lipidic agent and leading to a uniform and homogeneous layer without agglomeration.
is a complexation process to improve the solubility and bioavailability of a poorly soluble active ingredient.
is a one step process using supercritical CO2 as a solvent to incorporate an active ingredient in an excipient matrix.
Custom development and manufacturing using Supercritical CO2
Purification, impregnation, extraction by Supercritical CO2 for Pharmaceutical applications.
The cGMP supercritical fluids technology platform is able:
- to develop or transfer your already own developed process
- to perform clinical and commercial batches
Feasibility Study => Development => Production
The Supercritical CO2 division brings to its cutomers, the existing structures and expertises in the group Pierre Fabre also in the analytical and regulatory fields to permit to permit to its customers, according to their needs, a complete management of their project.
Cleaning of Medical Device
The properties of Supercritical CO2 are particularly well adapted to degrease in depth medical components without toxic chemical solvent. There is no drying step and no solvent residue after extraction and the mechanical properties of components treated by SC CO2 are preserved.
- Removal of extractables and leachables
- Reduction of Bioburden
Compliant with guidance on HVAC system
- Personal and material Airlock
- Qualification of equipment
- ISO 7 Clean room with air handling control (particles, bacteria)