Pierre Fabre
New ways to care  

  As they get older, men's risk of facing certain health challenges increases: Cardiovascular diseases, urinary problems, diabetes, cancer, depression... The onset of symptoms may appear to be silent and even if they become more frequent, they may not seem significant. That's why, to mark Men's Health Month, we're launching an awareness campaign aimed at encouraging men over 50 to take care of their health. Did you know? In somes countries (ex: in France), hypertension (high blood pressure) is more common in men than in women over the age of 50.  25% of French people aged 45 to 54 have hypertension, and about 50% are diagnosed (1). The prevalence of type 2 diabetes increases with age and is higher in men than in women of the same age group.In French men aged 45-54, the number of cases is multiplied by a factor of 16 (2).. The probability of having a stroke increases markedly after age 50 in men.Of the 120,000 myocardial infarctions (heart attacks) detected each year, 1/3 occur in people under 60 (3).. Cholesterol :  45% of French men aged 45-54 present an increase in bad LDL cholesterol levels (4). Colorectal cancer: 85-90% of colon cancers occur after age 50, with 610,000 men affected worldwide each year(11). Only 35.4% (in 2021-2022) of French people aged 50 to 74 underwent the recommended screenings (9)...   5 essential screenings for men over 50 for early diagnosis 1.    Colorectal cancer: search for blood in the stools (screening test, +/-coloscopy). 2.    Prostate cancer: digital rectal examination, PSA dosage (Prostate Specific Antigen)  3.   Type 2 diabetes: blood test 4.    High cholesterol: blood test 5.    Skin cancer: dermatological examination   After the age of 50, more than half of all men suffer from urinary problems  The frequent and urgent need to urinate, delayed drops, frequent night-time trips to the toilet, loss of libido, urinary incontinence... Most of these "private" problems are common among men, especially after the age of 50. Did you know? 1 in 2 men over 50 suffer from urinary problems that may be linked to Benign Prostatic Hyperplasia (5). 25% of men over 50 suffer from erectile dysfunction (ED) (6). 10-12% of men suffer from Overactive Bladder (OAB) after age 50 (7).. Over 71,000 men over the age of 50 develop prostate cancer every year, with an average of 9,000 prostate cancer deaths per year (8). Benign Prostatic Hyperplasia In men of a certain age, urinary disorders are very often linked to what is known as "prostate enlargement" or "Benign Prostatic Hyperplasia" (BPH). The prostate is a chestnut-sized gland located under the bladder, in front of the rectum. It surrounds the upper part of the urethra, the urinary canal that exits the bladder and allows the passage of urine and semen.

The script of the video.   •    Could you please introduce yourself? Hi, my name is Selina Jansky. I’m 31 years old and I live and work in Germany. I joined Pierre Fabre as an MSL about 1,5 years ago. •    What is your professional background before being an MSL?  I’m a molecular biologist by training and before starting as an MSL, I worked at the German Cancer Research Center in Heidelberg, for my PhD and Postdoc. •    How would you define the MSL role? MSL is the direct link between pharmaceutical companies and healthcare professionals. And he contributes to this exchange by discussing current scientific and clinical data, but also by collecting insights from daily clinical practice. •    What do you like about being an MSL? I really like about being an MSL, that I’m able to use my scientific background and stay up to date through latest scientific advancements. But also at the same time, I can contribute to patient care by helping healthcare professionals to make informed decisions about treatment options. •    What is the most difficult thing for you about being an MSL? HCPs are very busy and therefore, especially at the beginning, it can sometimes be difficult to get appointments and be able to talk to physicians. •    What is the essential quality of an MSL for you? I think for an MSL that it is essential to be an excellent communicator and especially to adapt communication to different audiences. •    What motivates you to get up in the morning as an MSL? What really motivates me in the morning, is that every day is really different. The job has a lot of variety and you get to meet many different people. •    What is your most beautiful emotion experienced as an MSL? It always makes me really happy to hear success stories from physicians who talk about patients who benefited from new therapies. •    Any words or advice for someone wanting to become an MSL? My advice would be for someone interested in becoming an MSL to talk to someone who is already experienced as an MSL as he ca give more detailed insights into the daily work and responsibilities.     Know more about MSL

Breast cancer is the most commonly diagnosed cancer in women1, with more than 2.2 million new cases reported each year worldwide.2  It accounts for 1 in 4 annual cancer cases globally.1 Breast cancer is the leading cause of death by cancer in women.2   Although more frequent after age 50, breast cancer can also occur in younger patients.1 An estimated 20% of breast cancer cases in Europe occur in women when they are younger than 50 years old.1 Also, even though most breast cancer cases occur in women, it can also occur in men (around 1% of cases).3  Importance of early detection  Early detection is key. Detecting cancer at an early stage significantly improves the prospects for treatment success. Being aware of your breasts' usual appearance and feel is important, and you should immediately inform your healthcare provider of any alterations. The most common symptoms of breast cancer are changes in the breasts, the lump in the breast being the most common, but not the only one.3  The following signs that should alert women and men:3  A lump in the breast  Change in the size or shape of the breast  Dimpling of the skin or thickening in the breast tissue  An inverted nipple  Rash on the nipple  Discharge from the nipple  Swelling or a lump in the armpit  Pain or discomfort in the breast that doesn’t go away  Skin redness  Skin thickening  In most cases, breast cancer is asymptomatic. Getting regular screening tests is the most reliable way to detect breast cancer early. Check with your doctor if you are eligible and get information about screening frequency. 4,5         How to do self-examination?4 

  The script of the video. •    Could you please introduce yourself? Hello, I’m Miaomiao Zhang, I’m 27 years old. I come from China medical team. I became an MSL in Pierre Fabre and it has been two years. •    What is your professional background before being an MSL?  I studied clinical pharmacology at Chongqing Medical University in China and then I went abroad for further study at University of Glasgow. I finally got my master’s degree. •    How would you define the MSL role? I think MSL is a role acting as a bridge between the company and the experts, providing scientific information in an accurate and objective way. •    What do you like about being an MSL? Being a MSL can apply my professional knowledge to the practical work, and I think it is meaningful to help the doctors to improve their treatment strategies. •    What is the most difficult thing for you about being an MSL? The development and the changes in the field of oncology treatment are very rapid, which requires us to keep learning cutting-edge knowledge worldwide. I think it’s very difficult. •    What is the essential quality of an MSL for you? I summarize into three words: professionalism, communication and coordination. •    What motivates you to get up in the morning as an MSL? MSL's working scenarios are varied, so I’m always able to play my role in different occasions, which keeps me feeling fresh and enthusiastic about my work. •    What is your most beautiful emotion experienced as an MSL? Being as an MSL makes me feel valuable when I deeply communicate with the doctors and I could get to the good feedback from them.  •    Any words or advice for someone wanting to become an MSL? If someone wants to be a good MSL, he needs to maintain the passion for learning about the disease area and keeps the love of science just trying to work as an expert in the field      Know more about MSL

Join us in recognizing World Lymphoma Awareness Day, 15th September, a day dedicated to raising awareness of lymphomas, which are cancers of the lymphocytes or white blood cells.  This day sheds light on a type of cancer with more than 80 subtypes and that affects up to 864,000 people world wide1,2. One of these subtypes is Post-Transplant Lymphoproliferative disorder (PTLD). PLTD is a rare disease characterized by the development of lymphoid neoplasms after solid organ or hematopoietic stem cell transplantation3,4.  As we mark World Lymphoma Awareness Day this September, Pierre Fabre Laboratories is dedicated to shine a light on this rare condition. PTLD is a potentially life-threatening complication that can occur after an organ transplant. The occurrence of PTLD varies from 2% to 20%, depending on the type of transplant5. Our commitment is to educate, support, and inspire action among patients, healthcare professionals, and the broader community to improve understanding and management of PTLD. Understanding PTLD  Post-Transplant Lymphoproliferative Disorder (PTLD) is a spectrum of lymphoid proliferations that can occur following hematopoietic (bone marrow) or solid organ transplantation3,4. Patients who receive a transplant are subjected to a strong immunosuppressive regimen to prevent rejection, which makes individuals susceptible to the disease, resulting in very few cases of PTLD5.PTLD is characterized by proliferation of white blood cells (B lymphocytes) which often are infected by the Epstein Barr virus.6 What causes PTLD? •    Although children who are infected with Epstein Barr Virus (EBV), also called infectious mononucleosis, may not display any symptoms, the virus can lead to the development of mononucleosis in adolescents and adults.7•    It is estimated that 90% of the world-wide adult population has life-long EBV infection.7•    Immunosuppressive therapy can produce the reactivation of EBV-infected B lymphocytes.8,9•    In an immunosuppressed patient, T-cells are low in number, and they cannot properly eliminate the virus.10 This can lead to the rapid proliferation of EBV-infected B-cells, causing PTLD.6 Prevalence and Risk of PTLD PTLD occurs in solid organ transplants and in hematopoietic stem cell transplantation3,4.         The risk of developing PTLD depends on the degree of immunosuppression, the EBV serostatus and age.8,9,13,14 •    The more immunosuppressed the patient is, the greater the risk of developing PTLD.12,14 The degree of compatibility between recipient and donor is very important, especially in the case of stem cell transplants.12,14•    PTLD can occur when the transplanted patient’s own EBV is reactivated or because the EBV from the donor is reactivated in the patient.8,9•    Children under 10 years and adults over 50 years (haematopoietic transplant) or 60 years (solid organ transplant) are at higher risk of developing PTLD.12,14 Symptomatology and diagnosis Some of the common PTLD symptoms are: 8,9,14